PPA2
Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function. Belongs to the PPase family. Detected in brain, gastric carcinoma, lung, ovary, skeletal muscle, umbilical cord blood and a cell line derived from kidney proximal tubule epithelium. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.6.1.1; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial |
Chromosomal Location of mouse Ortholog: 3|3 G3 |
Cellular Component:
cytoplasm; mitochondrion; synapse
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Molecular Function:
hydrolase activity; inorganic diphosphate phosphatase activity; magnesium ion binding; metal ion binding; protein serine/threonine phosphatase activity
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Biological Process:
diphosphate metabolic process; phosphate-containing compound metabolic process; regulation of mitochondrial membrane potential
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Reference #:
Q91VM9
(UniProtKB)
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Alt. Names/Synonyms: 1110013G13Rik; Inorganic pyrophosphatase 2, mitochondrial; IPYR2; MGC6539; Ppa2; PPase 2; pyrophosphatase (inorganic) 2; Pyrophosphate phospho-hydrolase 2; Sid63; Sid6306
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Gene Symbols: Ppa2
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Molecular weight:
38,115 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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