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RNF10
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination. Belongs to the RNF10 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 12q24.31 |
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Cellular Component:
cytoplasm; extrinsic component of postsynaptic density membrane; glutamatergic synapse; nucleus
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Molecular Function:
metal ion binding; protein binding; transcription cis-regulatory region binding; ubiquitin protein ligase activity
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Biological Process:
negative regulation of Schwann cell proliferation; positive regulation of DNA-templated transcription; positive regulation of myelination; positive regulation of transcription by RNA polymerase II; postsynapse to nucleus signaling pathway; protein autoubiquitination; protein monoubiquitination; ribosome-associated ubiquitin-dependent protein catabolic process
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Reference #:
Q8N5U6
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase RNF10; epididymis secretory sperm binding protein; KIAA0262; MGC126758; MGC126764; RIE2; RING finger protein 10; RNF10
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Gene Symbols: RNF10
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Molecular weight:
89,927 Da
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Basal Isoelectric point:
6.48
Predict pI for various phosphorylation states
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