ENY2 Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Belongs to the ENY2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 8q23.1
Cellular Component:  DUBm complex; mitochondrion; nuclear pore nuclear basket; nucleoplasm; SAGA complex; transcription export complex 2
Molecular Function:  nuclear receptor transcription coactivator activity; protein binding; transcription coactivator activity
Biological Process:  histone deubiquitination; negative regulation of insulin secretion involved in cellular response to glucose stimulus; poly(A)+ mRNA export from nucleus; positive regulation of transcription, DNA-templated; transcription elongation from RNA polymerase II promoter
Reference #:  Q9NPA8 (UniProtKB)
Alt. Names/Synonyms: DC6; e(y)2; enhancer of yellow 2 homolog; enhancer of yellow 2 transcription factor; Enhancer of yellow 2 transcription factor homolog; ENY2; ENY2 transcription and export complex 2 subunit; FLJ20480; Sus1; Transcription and mRNA export factor ENY2
Gene Symbols: ENY2
Molecular weight: 11,529 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
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ENY2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein