PKCA a classical protein kinase C (PKC) downstream of many receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators. Involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Associated with increases in cellular polarization and motility. During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level, and the regulation of calcium-induced platelet aggregation. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. Belongs to the AGC Ser/Thr protein kinase family, PKC subfamily. Note: This description may include information from UniProtKB.
Protein type: AGC group; Alpha subfamily; EC; Kinase, protein; Oncoprotein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 17q24.2
Cellular Component:  alphav-beta3 integrin-PKCalpha complex; cytoplasm; cytosol; endoplasmic reticulum; mitochondrial membrane; nucleoplasm; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  ATP binding; enzyme binding; histone kinase activity (H3-T6 specific); integrin binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity; zinc ion binding
Biological Process:  angiogenesis; apoptotic signaling pathway; axon guidance; cell adhesion; desmosome assembly; ERBB2 signaling pathway; histone H3-T6 phosphorylation; mitotic nuclear envelope disassembly; negative regulation of glial cell apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; platelet activation; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of bone resorption; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; protein phosphorylation; regulation of insulin secretion; regulation of mRNA stability; regulation of platelet aggregation; response to interleukin-1
Reference #:  P17252 (UniProtKB)
Alt. Names/Synonyms: AAG6; aging-associated gene 6; KPCA; MGC129900; MGC129901; PKC-A; PKC-alpha; PKCA; PKCalpha; PKCI+/-; PRKACA; PRKCA; protein kinase C; protein kinase C alpha; Protein kinase C alpha type; protein kinase C, alpha
Gene Symbols: PRKCA
Molecular weight: 76,750 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene