MRLC2 Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Ubiquitously expressed in various hematopoietic cells. Note: This description may include information from UniProtKB.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 17|17 E1.3
Cellular Component:  apical part of cell; myosin II complex; protein-containing complex; stress fiber; Z disc
Molecular Function:  myosin heavy chain binding
Biological Process:  regulation of cell shape
Reference #:  Q3THE2 (UniProtKB)
Alt. Names/Synonyms: 1500001M02Rik; C77744; ML12B; MLC20; Mrlc2; Myl12b; Mylc2b; myosin light chain, regulatory B; Myosin regulatory light chain 12B; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2; myosin regulatory light chain-like; myosin, light chain 12B, regulatory; OTTMUSP00000017496; RLC-B
Gene Symbols: Myl12b
Molecular weight: 19,779 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  TGF-ß Signaling
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MRLC2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene