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MRLC2
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. Ubiquitously expressed in various hematopoietic cells. Note: This description may include information from UniProtKB.
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| Protein type: Contractile |
| Chromosomal Location of Human Ortholog: 18p11.31 |
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Cellular Component:
cell cortex region; cytosol; myosin complex
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Molecular Function:
calcium ion binding; protein binding
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Biological Process:
muscle contraction
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Reference #:
O14950
(UniProtKB)
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Alt. Names/Synonyms: ML12B; MLC-2; MLC-2A; MLC-B; MLC20; MRLC2; MYL12B; MYLC2B; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2; myosin, light chain 12B, regulatory; SHUJUN-1
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Gene Symbols: MYL12B
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Molecular weight:
19,779 Da
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Basal Isoelectric point:
4.71
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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TGF-ß Signaling
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