SPCS1 Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS1 family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Cofactor and Vitamin Metabolism - biotin; EC 3.4.-.-; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of human Ortholog: 3p21.1
Cellular Component:  endoplasmic reticulum membrane; signal peptidase complex
Molecular Function:  protein binding
Biological Process:  protein targeting to ER; proteolysis; signal peptide processing; viral protein processing; virion assembly
Reference #:  Q9Y6A9 (UniProtKB)
Alt. Names/Synonyms: HSPC033; Microsomal signal peptidase 12 kDa subunit; signal peptidase 12kDa; signal peptidase complex 12 kDa subunit; Signal peptidase complex subunit 1; signal peptidase complex subunit 1 homolog; signal peptidase complex subunit 1 homolog (S. cerevisiae); SPase 12 kDa subunit; SPC1; SPC12; SPCS1; YJR010C-A
Gene Symbols: SPCS1
Molecular weight: 18,298 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein