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NHE1
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Kidney and intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family |
| Chromosomal Location of Human Ortholog: 4 D2.3|4 66.25 cM |
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Cellular Component:
apical plasma membrane; basolateral plasma membrane; cation-transporting ATPase complex; cell surface; cytoplasm; endoplasmic reticulum; integral component of membrane; integral component of plasma membrane; intercalated disc; membrane; membrane raft; mitochondrion; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; sarcolemma; T-tubule
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Molecular Function:
antiporter activity; calcium-dependent protein binding; calmodulin binding; potassium:proton antiporter activity; protein phosphatase 2B binding; sodium:proton antiporter activity; solute:proton antiporter activity
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Biological Process:
cardiac muscle cell differentiation; cation transport; cellular response to acidic pH; cellular response to epinephrine stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular sodium ion homeostasis; ion transport; negative regulation of apoptotic process; neuron death; positive regulation of action potential; positive regulation of apoptotic process; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of calcium:sodium antiporter activity; positive regulation of cardiac muscle hypertrophy; positive regulation of cell growth; positive regulation of intracellular signal transduction; positive regulation of mitochondrial membrane permeability; positive regulation of the force of heart contraction; positive regulation of transcription by RNA polymerase II; potassium ion transmembrane transport; proton transmembrane transport; regulation of cardiac muscle contraction by calcium ion signaling; regulation of intracellular pH; regulation of pH; regulation of sensory perception of pain; regulation of the force of heart contraction; regulation of the force of heart contraction by cardiac conduction; response to acidic pH; response to muscle stretch; response to organic cyclic compound; sodium ion import across plasma membrane; sodium ion transport; transmembrane transport
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Reference #:
Q61165
(UniProtKB)
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Alt. Names/Synonyms: Apnh; AW554487; Na(+)/H(+) exchanger 1; Na+/H+ antiporter; Na+/H+, amiloride sensitive; NHE-1; Nhe1; OTTMUSP00000011959; SL9A1; Slc9a1; slow-wave epilepsy; Sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1; Solute carrier family 9 member 1; solute carrier family 9, member 1; swe
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Gene Symbols: Slc9a1
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Molecular weight:
91,468 Da
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Basal Isoelectric point:
6.65
Predict pI for various phosphorylation states
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