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Nur77
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. Belongs to the nuclear hormone receptor family. NR4 subfamily. Fetal muscle and adult liver, brain and thyroid. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; DNA-binding; Nuclear receptor |
| Chromosomal Location of human Ortholog: 12q13.13 |
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Cellular Component:
chromatin; cytosol; mitochondrion; nuclear membrane; nucleoplasm; nucleus; presynapse; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; lipopolysaccharide binding; nuclear glucocorticoid receptor binding; nuclear receptor activity; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
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Biological Process:
apoptotic process; cell migration involved in sprouting angiogenesis; cellular response to corticotropin-releasing hormone stimulus; cellular response to fibroblast growth factor stimulus; cellular response to vascular endothelial growth factor stimulus; detection of lipopolysaccharide; endothelial cell chemotaxis; fat cell differentiation; intracellular receptor signaling pathway; negative regulation of cell cycle; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; neurotransmitter secretion involved in regulation of skeletal muscle contraction; non-canonical inflammasome complex assembly; positive regulation of apoptotic process; positive regulation of endothelial cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; regulation of type B pancreatic cell proliferation; response to amphetamine; response to electrical stimulus; signal transduction; skeletal muscle cell differentiation; transcription by RNA polymerase II
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Reference #:
P22736
(UniProtKB)
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Alt. Names/Synonyms: Early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; MGC9485; N10; NAK-1; NAK1; nerve growth factor IB nuclear receptor variant 1; NGFIB; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nuclear receptor subfamily 4immunitygroup A member 1; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3; TR3 orphan receptor
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Gene Symbols: NR4A1
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Molecular weight:
64,463 Da
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Basal Isoelectric point:
6.82
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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