CNTN2
In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion. Belongs to the immunoglobulin superfamily. Contactin family. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Cell development/differentiation; Membrane protein, GPI anchor |
Chromosomal Location of human Ortholog: 1q32.1 |
Cellular Component:
axon; axon initial segment; cell surface; juxtaparanode region of axon; myelin sheath; neuronal cell body; node of Ranvier; plasma membrane; postsynaptic membrane; side of membrane; synapse
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Molecular Function:
carbohydrate binding; cell-cell adhesion mediator activity; protein binding; protein self-association
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Biological Process:
adult walking behavior; axon guidance; axonal fasciculation; cell adhesion; central nervous system myelination; cerebral cortex GABAergic interneuron migration; clustering of voltage-gated potassium channels; dendrite self-avoidance; establishment of localization in cell; establishment of protein localization to juxtaparanode region of axon; fat cell differentiation; G protein-coupled adenosine receptor signaling pathway; homophilic cell adhesion via plasma membrane adhesion molecules; learning; microtubule cytoskeleton organization; negative regulation of neuron differentiation; positive regulation of adenosine receptor signaling pathway; positive regulation of protein processing; presynaptic membrane organization; protein localization to juxtaparanode region of axon; protein processing; receptor internalization; reduction of food intake in response to dietary excess; regulation of astrocyte differentiation; regulation of axon diameter; regulation of cell morphogenesis involved in differentiation; regulation of neuronal synaptic plasticity
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Disease: Epilepsy, Familial Adult Myoclonic, 5
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Reference #:
Q02246
(UniProtKB)
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Alt. Names/Synonyms: Axonal glycoprotein TAG-1; Axonin-1; axonin-1 cell adhesion molecule; AXT; CNTN2; contactin 2; contactin 2 (axonal); contactin 2 (transiently expressed); Contactin-2; DKFZp781D102; FAME5; FLJ42746; MGC157722; TAG-1; TAG1; TAX; TAX-1; TAX1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein
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Gene Symbols: CNTN2
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Molecular weight:
113,393 Da
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Basal Isoelectric point:
8.11
Predict pI for various phosphorylation states
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CST Pathways:
NF-kB Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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