ANPA natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction. Note: This description may include information from UniProtKB.
Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.
Chromosomal Location of Human Ortholog: 3 F1|3 39.23 cM
Cellular Component:  guanylate cyclase complex, soluble; integral component of membrane; membrane; plasma membrane; receptor complex
Molecular Function:  adenylate cyclase activity; ATP binding; guanylate cyclase activity; hormone binding; lyase activity; natriuretic peptide receptor activity; nucleotide binding; peptide hormone binding; phosphorus-oxygen lyase activity; protein kinase activity; protein kinase binding
Biological Process:  cell surface receptor signaling pathway; cGMP biosynthetic process; cyclic nucleotide biosynthetic process; dopamine metabolic process; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP-mediated signaling; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of blood vessel size; signal transduction
Reference #:  P18293 (UniProtKB)
Alt. Names/Synonyms: AI893888; ANP-A; ANPR-A; ANPRA; Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; GC-A; Guanylate cyclase A; guanylyl cyclase-A; MGC117511; natriuretic peptide receptor 1; Nppa receptor; NPR-A; Npr1; Npra; Pndr
Gene Symbols: Npr1
Molecular weight: 119,109 Da
Basal Isoelectric point: 6.43  Predict pI for various phosphorylation states
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ANPA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene