nNOS Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Belongs to the NOS family. Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 5 F|5 57.29 cM
Cellular Component:  azurophil granule; calyx of Held; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; glutamatergic synapse; membrane; membrane raft; mitochondrial outer membrane; mitochondrion; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; postsynaptic density; postsynaptic density, intracellular component; postsynaptic specialization, intracellular component; protein-containing complex; sarcolemma; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; secretory granule; synapse; T-tubule; vesicle membrane; Z disc
Molecular Function:  ATPase binding; cadmium ion binding; calmodulin binding; enzyme binding; flavin adenine dinucleotide binding; FMN binding; heme binding; ion channel binding; metal ion binding; NADP binding; NADPH binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; oxidoreductase activity; phosphoprotein binding; protein binding; protein homodimerization activity; scaffold protein binding; sodium channel regulator activity; zinc ion binding
Biological Process:  arginine catabolic process; behavioral response to cocaine; cellular response to epinephrine stimulus; cellular response to growth factor stimulus; cellular response to mechanical stimulus; establishment of protein localization; exogenous drug catabolic process; multicellular organismal response to stress; negative regulation of apoptotic process; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell proliferation; negative regulation of cytosolic calcium ion concentration; negative regulation of heart contraction; negative regulation of hepatic stellate cell contraction; negative regulation of hydrolase activity; negative regulation of insulin secretion; negative regulation of iron ion transmembrane transport; negative regulation of neuron apoptotic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of potassium ion transport; negative regulation of serotonin uptake; negative regulation of vasoconstriction; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; oxidation-reduction process; peptidyl-cysteine S-nitrosylation; positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; positive regulation of blood vessel diameter; positive regulation of guanylate cyclase activity; positive regulation of histone acetylation; positive regulation of long-term synaptic potentiation; positive regulation of neuron death; positive regulation of peptidyl-serine phosphorylation; positive regulation of sodium ion transmembrane transport; positive regulation of the force of heart contraction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of heart contraction; regulation of neurogenesis; regulation of sensory perception of pain; regulation of sodium ion transport; response to estrogen; response to heat; response to hormone; response to lipopolysaccharide; response to peptide hormone; retrograde trans-synaptic signaling by nitric oxide; striated muscle contraction; synaptic signaling by nitric oxide; vasodilation
Reference #:  Q9Z0J4 (UniProtKB)
Alt. Names/Synonyms: 2310005C01Rik; bNOS; Constitutive NOS; N-NOS; NC-NOS; neuronal nitric oxide synthase; Neuronal NOS; nitric oxide synthase 1, neuronal; Nitric oxide synthase, brain; nNOS; NO; NOS; NOS type I; Nos-1; NOS-I; Nos1; OTTMUSP00000017465; Peptidyl-cysteine S-nitrosylase NOS1
Gene Symbols: Nos1
Molecular weight: 160,472 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene