NMDAR2B Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily. Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6 G1|6 66.38 cM
Cellular Component:  apical dendrite; cell junction; cell surface; cytoplasm; dendritic spine; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic density membrane; integral component of presynaptic membrane; membrane; neuron projection; neuronal cell body; NMDA selective glutamate receptor complex; parallel fiber to Purkinje cell synapse; plasma membrane; postsynapse; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic membrane; synapse; synaptic cleft; synaptic membrane; synaptic vesicle; terminal bouton; Z disc
Molecular Function:  beta-catenin binding; calcium channel activity; cation channel activity; cell adhesion molecule binding; D2 dopamine receptor binding; drug binding; extracellularly glutamate-gated ion channel activity; glutamate binding; glutamate-gated calcium ion channel activity; glycine binding; interleukin-1 receptor binding; ion channel activity; ionotropic glutamate receptor activity; ionotropic glutamate receptor binding; metal ion binding; neurotransmitter binding; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; NMDA glutamate receptor activity; protein binding; protein heterodimerization activity; scaffold protein binding; signaling receptor activity; signaling receptor binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; zinc ion binding
Biological Process:  action potential; associative learning; behavioral fear response; behavioral response to pain; calcium ion transmembrane import into cytosol; calcium ion transport; cation transport; chemical synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; excitatory postsynaptic potential; fear response; in utero embryonic development; ion transport; ionotropic glutamate receptor signaling pathway; learning; learning or memory; long-term synaptic potentiation; memory; negative regulation of dendritic spine maintenance; NMDA selective glutamate receptor signaling pathway; positive regulation of cell death; positive regulation of cysteine-type endopeptidase activity; positive regulation of glutamate secretion; positive regulation of long-term synaptic potentiation; positive regulation of neuron death; positive regulation of synaptic transmission; protein heterotetramerization; receptor clustering; regulation of long-term neuronal synaptic plasticity; regulation of MAPK cascade; regulation of neuronal synaptic plasticity; regulation of postsynaptic cytosolic calcium ion concentration; regulation of postsynaptic membrane potential; regulation of protein kinase A signaling; regulation of synaptic plasticity; response to ethanol; response to hypoxia; response to organonitrogen compound; rhythmic process; sensitization; sensory organ development; startle response; suckling behavior
Reference #:  Q01097 (UniProtKB)
Alt. Names/Synonyms: AW490526; GluN; GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); Grin2b; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; NMDA; NMDAR2B; NMDE2; NR2B; OTTMUSP00000017581
Gene Symbols: Grin2b
Molecular weight: 165,959 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene