PPP2R2B
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. Belongs to the phosphatase 2A regulatory subunit B family. Brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
Chromosomal Location of mouse Ortholog: 18|18 B3 |
Cellular Component:
cytoplasm; cytoskeleton; cytosol; membrane; mitochondrial outer membrane; mitochondrion; protein phosphatase type 2A complex
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Molecular Function:
protein phosphatase regulator activity; protein-containing complex binding
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Biological Process:
apoptotic process; mitochondrial fission; mitochondrial fragmentation involved in apoptotic process; positive regulation of neuron apoptotic process; protein targeting to mitochondrion; regulation of phosphoprotein phosphatase activity
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Reference #:
Q6ZWR4
(UniProtKB)
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Alt. Names/Synonyms: 2900026H06Rik; 2ABB; 6330404L05Rik; E130009M08Rik; MGC113781; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A-; PP2A-PR55B; Ppp2r2b; PR55-B; PR55-BETA; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2, regulatory subunit B, beta; SCA; SCA12; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
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Gene Symbols: Ppp2r2b
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Molecular weight:
51,710 Da
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Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
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