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PCSK5
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Belongs to the peptidase S8 family. Expressed in T-lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.21.-; Membrane protein, integral; Protease |
| Chromosomal Location of human Ortholog: 9q21.13 |
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Cellular Component:
extracellular region; extracellular space; Golgi apparatus; Golgi lumen; secretory granule
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Molecular Function:
endopeptidase activity; peptidase activity; peptide binding; protein binding; serine-type endopeptidase activity
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Biological Process:
anterior/posterior pattern specification; cardiac septum development; cell-cell signaling; coronary vasculature development; cytokine biosynthetic process; determination of left/right symmetry; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; heart development; kidney development; limb morphogenesis; nerve growth factor processing; peptide biosynthetic process; peptide hormone processing; protein processing; regulation of lipoprotein lipase activity; renin secretion into blood stream; respiratory tube development; signal peptide processing; viral life cycle
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Reference #:
Q92824
(UniProtKB)
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Alt. Names/Synonyms: hPC6; PC5; PC6; PC6A; PCSK5; prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; protease PC6; SPC6; subtilase; Subtilisin/kexin-like protease PC5
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Gene Symbols: PCSK5
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Molecular weight:
206,942 Da
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Basal Isoelectric point:
5.71
Predict pI for various phosphorylation states
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