PCSK5 Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Belongs to the peptidase S8 family. Expressed in T-lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.-; Membrane protein, integral; Protease
Chromosomal Location of human Ortholog: 9q21.13
Cellular Component:  extracellular region; extracellular space; Golgi apparatus; Golgi lumen; secretory granule
Molecular Function:  endopeptidase activity; peptidase activity; peptide binding; protein binding; serine-type endopeptidase activity
Biological Process:  anterior/posterior pattern specification; cardiac septum development; cell-cell signaling; coronary vasculature development; cytokine biosynthetic process; determination of left/right symmetry; embryo implantation; embryonic digestive tract development; embryonic skeletal system development; heart development; kidney development; limb morphogenesis; nerve growth factor processing; peptide biosynthetic process; peptide hormone processing; protein processing; regulation of lipoprotein lipase activity; renin secretion into blood stream; respiratory tube development; signal peptide processing; viral life cycle
Reference #:  Q92824 (UniProtKB)
Alt. Names/Synonyms: hPC6; PC5; PC6; PC6A; PCSK5; prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; protease PC6; SPC6; subtilase; Subtilisin/kexin-like protease PC5
Gene Symbols: PCSK5
Molecular weight: 206,942 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene