NFAT1
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Isoform 1 is highly expressed in the small intestine, heart, testis, prostate, thymus, placenta and thyroid. Isoform 3 is highly expressed in stomach, uterus, placenta, trachea and thyroid. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factorChromosomal Location of mouse Ortholog: 2 H3|2 88.91 cM
Cellular Component:
chromatin; cytoplasm; cytosol; nucleoplasm; nucleus; ribonucleoprotein complex; transcription factor AP-1 complex; transcription regulator complex
Molecular Function:
14-3-3 protein binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; molecular adaptor activity; phosphatase binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription factor binding
Biological Process:
B cell receptor signaling pathway; calcineurin-NFAT signaling cascade; cartilage development; cell migration; cellular response to calcium ion; cytokine production; DNA damage response; gene expression; myotube cell development; ncRNA transcription; negative regulation of transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell differentiation; positive regulation of B cell proliferation; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of myoblast fusion; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to xenobiotic stimulus; transcription by RNA polymerase II
Reference #:
Q60591
(UniProtKB)
Alt. Names/Synonyms: AI607462; NF-ATc2; NF-ATp; NFA; NFAC2; NFAT pre-existing subunit; Nfat1; NFAT1-D; NFATc2; Nfatp; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; Nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; OTTMUSP00000017171; OTTMUSP00000017173; T-cell transcription factor NFAT1
Gene Symbols: Nfatc2
Molecular weight:
100,020 Da
Basal Isoelectric point:
6.29
Predict pI for various phosphorylation states
CST Pathways:
B Cell Receptor Signaling
|
T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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NFAT1
1A02 - N=392-678 (human)
1OWR - M/N/P/Q=396-678 (human)
1P7H - L/M/N/O=396-678 (human)
1PZU - B/D/H/I/L/M=396-678 (human)
1S9K - C=399-678 (human)
2AS5 - M/N=392-678 (human)
2O93 - L/M/O=392-678 (human)
3QRF - M/N=396-678 (human)
8OW4 - A/B=391-678 (human)
8R07 - A/B=575-678 (human)
8R3F - A/B=575-678 (human)
