HS3ST3A1 Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Belongs to the sulfotransferase 1 family. Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney. Note: This description may include information from UniProtKB.
Protein type: EC 2.8.2.23; Glycan Metabolism - glycosaminoglycan degradation; Glycan Metabolism - heparan sulfate biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 17p12
Cellular Component:  Golgi membrane; integral component of membrane
Molecular Function:  [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity; sulfotransferase activity
Biological Process:  glycosaminoglycan biosynthetic process
Reference #:  Q9Y663 (UniProtKB)
Alt. Names/Synonyms: 3-OST-3A; 30ST3A1; 3OST3A1; h3-OST-3A; heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1; Heparan sulfate 3-O-sulfotransferase 3A1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; heparan sulfate-glucosamine 3-sulfotransferase 3A1; heparin-glucosamine 3-O-sulfotransferase; HS3SA; HS3ST3A; HS3ST3A1
Gene Symbols: HS3ST3A1
Molecular weight: 44,900 Da
Basal Isoelectric point: 9.54  Predict pI for various phosphorylation states
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HS3ST3A1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene