SCN9A Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily. Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 3q21
Cellular Component:  axon; integral component of plasma membrane; plasma membrane; voltage-gated sodium channel complex
Molecular Function:  sodium ion binding; voltage-gated ion channel activity; voltage-gated sodium channel activity
Biological Process:  behavioral response to pain; inflammatory response; membrane depolarization during action potential; neuronal action potential; post-embryonic development; regulation of ion transmembrane transport; response to toxic substance; rhythmic excitation; sensory perception of pain; sodium ion transmembrane transport
Reference #:  O08562 (UniProtKB)
Alt. Names/Synonyms: Scn9a; Sodium channel protein type 9 subunit alpha; sodium channel, voltage-gated, type IX, alpha
Gene Symbols: Scn9a
Molecular weight: 226,039 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene