ELK3 May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. Belongs to the ETS family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 10 C2|10 48.04 cM
Cellular Component:  cytoplasm; mitochondrion; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; purine-rich negative regulatory element binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  angiogenesis; cell differentiation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; wound healing
Reference #:  P41971 (UniProtKB)
Alt. Names/Synonyms: D430049E23Rik; Elk-3; Elk3; ELK3, member of ETS oncogene family; Erp; Etrp; ETS domain-containing protein Elk-3; ETS-domain protein ELK-3; ETS-related protein ERP; ETS-related protein NET; Net; Sap-2
Gene Symbols: Elk3
Molecular weight: 44,414 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene