NEK6 Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. Ubiquitous, with highest expression in heart and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; NEK family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 2 B|2 24.41 cM
Cellular Component:  cytoplasm; cytoskeleton; cytosol; intracellular membrane-bounded organelle; microtubule organizing center; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  activating transcription factor binding; ATP binding; kinase activity; kinesin binding; magnesium ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transcription corepressor binding; transferase activity; ubiquitin protein ligase binding
Biological Process:  activation of protein kinase activity; apoptotic process; cell cycle; cell division; cellular response to DNA damage stimulus; chromosome segregation; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of mitotic metaphase/anaphase transition; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q9ES70 (UniProtKB)
Alt. Names/Synonyms: 1300007C09Rik; Nek6; Never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related expressed kinase 6; NIMA-related expressed kinase 6; NimA-related protein kinase 6; OTTMUSP00000013815; OTTMUSP00000013817; Serine/threonine-protein kinase Nek6
Gene Symbols: Nek6
Molecular weight: 35,742 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
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NEK6

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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene