N-Myc Positively regulates the transcription of MYCNOS in neuroblastoma cells. Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 12 A1.1|12 6.14 cM
Cellular Component:  nucleolus; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; kinase binding; protein binding; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  branching morphogenesis of an epithelial tube; cartilage condensation; embryonic digit morphogenesis; embryonic skeletal system morphogenesis; lung development; negative regulation of astrocyte differentiation; negative regulation of gene expression; negative regulation of reactive oxygen species metabolic process; positive regulation of cell death; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of mesenchymal cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of inner ear auditory receptor cell differentiation; regulation of transcription, DNA-templated
Reference #:  P03966 (UniProtKB)
Alt. Names/Synonyms: bHLHe3; bHLHe37; c-nmyc; Mycn; N-my; N-myc; N-myc proto-oncogene protein; neuroblastoma myc-related oncogene 1; Nmy; Nmyc; Nmyc-; Nmyc-1; Nmyc1; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Gene Symbols: Mycn
Molecular weight: 49,572 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene