UBE2L3 Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1. Ubiquitous, with highest expression in testis. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Nuclear receptor co-regulator; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; ubiquitin ligase complex
Molecular Function:  ATP binding; enzyme binding; protein binding; transcription coactivator activity; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activator activity; ubiquitin-protein transferase activity
Biological Process:  cell cycle phase transition; cell proliferation; cellular protein modification process; cellular response to glucocorticoid stimulus; cellular response to steroid hormone stimulus; positive regulation of nucleic acid-templated transcription; positive regulation of protein ubiquitination; positive regulation of ubiquitin-protein transferase activity; protein K11-linked ubiquitination; protein polyubiquitination; protein ubiquitination; regulation of transcription, DNA-templated; ubiquitin-dependent protein catabolic process
Reference #:  P68036 (UniProtKB)
Alt. Names/Synonyms: E2-F1; L-UBC; UB2L3; UBCE7; UBCH7; UbcM4; UBE2L3; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2-F1; ubiquitin-conjugating enzyme E2L 3; ubiquitin-conjugating enzyme UBCH7; Ubiquitin-protein ligase L3
Gene Symbols: UBE2L3
Molecular weight: 17,862 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB