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MYPT1
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Expressed in striated muscles, specifically in type 2a fibers (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
| Chromosomal Location of mouse Ortholog: 10 D1|10 56.33 cM |
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Cellular Component:
A band; actin cytoskeleton; centrosome; contractile fiber; cytoplasm; cytoskeleton; cytosol; kinetochore; nucleolus; plasma membrane; PTW/PP1 phosphatase complex; Z disc
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Molecular Function:
14-3-3 protein binding; enzyme inhibitor activity; phosphatase regulator activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding
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Biological Process:
cellular response to xenobiotic stimulus; centrosome cycle; mitotic cell cycle; negative regulation of catalytic activity; positive regulation of myosin-light-chain-phosphatase activity; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transduction
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Reference #:
Q9DBR7
(UniProtKB)
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Alt. Names/Synonyms: 1200015F06Rik; 5730577I22Rik; AA792106; AV099298; D10Ertd625; D10Ertd625e; MGC159084; Myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; Myosin phosphatase-targeting subunit 1; Mypt; Mypt1; Ppp1r12a; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1, regulatory subunit 12A
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Gene Symbols: Ppp1r12a
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Molecular weight:
114,996 Da
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Basal Isoelectric point:
5.38
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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