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CNOT4 iso2
Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 6|6 B1 |
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Cellular Component:
CCR4-NOT complex; cytoplasm; nucleus
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Molecular Function:
metal ion binding; nucleic acid binding; RNA binding; transferase activity; ubiquitin-protein transferase activity
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Biological Process:
protein autoubiquitination; protein ubiquitination; regulation of megakaryocyte differentiation; ubiquitin-dependent protein catabolic process
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Reference #:
Q8BT14-2
(UniProtKB)
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Alt. Names/Synonyms: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; Cnot4; CNOT4 iso2; E3 ubiquitin-protein ligase CNOT4; negative regulator of transcription 4; Not; Not4; Not4h; Not4hp; Potential transcriptional repressor NOT4Hp; Q8BT14-2; RING-type E3 ubiquitin transferase CNOT4; transcriptional repressor NOT4Hp
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Gene Symbols: Cnot4
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Molecular weight:
63,026 Da
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Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
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