MYPT1 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Expressed in striated muscles, specifically in type 2a fibers (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 12q21.2-q21.31
Cellular Component:  A band; actin cytoskeleton; centrosome; contractile fiber; cytosol; kinetochore; nucleoplasm; PTW/PP1 phosphatase complex; Z disc
Molecular Function:  14-3-3 protein binding; enzyme inhibitor activity; phosphatase regulator activity; protein binding; protein kinase binding
Biological Process:  cellular response to drug; centrosome cycle; G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of catalytic activity; positive regulation of myosin-light-chain-phosphatase activity; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transduction
Disease: Genitourinary And/or Brain Malformation Syndrome
Reference #:  O14974 (UniProtKB)
Alt. Names/Synonyms: GUBS; M130; MBS; MGC133042; myosin binding subunit; Myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; Myosin phosphatase-targeting subunit 1; MYPT1; PPP1R12A; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; Protein phosphatase myosin-binding subunit
Gene Symbols: PPP1R12A
Molecular weight: 115,281 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MYPT1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein