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Myc
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor |
| Chromosomal Location of Human Ortholog: 15 D1|15 26.19 cM |
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Cellular Component:
axon; cytoplasm; nuclear body; nuclear chromatin; nuclear envelope; nuclear euchromatin; nucleolus; nucleoplasm; nucleoplasmic reticulum; nucleus; perinuclear region of cytoplasm; protein-containing complex; rough endoplasmic reticulum; spindle
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Molecular Function:
activating transcription factor binding; core promoter binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; eukaryotic initiation factor eIF2 binding; mRNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein-containing complex binding; proximal promoter sequence-specific DNA binding; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding; ubiquitin protein ligase binding
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; amino acid transport; B cell apoptotic process; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell cycle arrest; cell proliferation; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to drug; cellular response to hypoxia; cellular response to interferon-alpha; chromatin remodeling; chromosome organization; detection of mechanical stimulus involved in sensory perception of sound; DNA-templated transcription, initiation; ERK1 and ERK2 cascade; glucose metabolic process; inner mitochondrial membrane organization; intrinsic apoptotic signaling pathway in response to DNA damage; lactic acid secretion; MAPK cascade; middle ear morphogenesis; negative regulation of cell death; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of glucose import; negative regulation of monocyte differentiation; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; pigmentation; positive regulation of apoptotic signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of B cell apoptotic process; positive regulation of catalytic activity; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of cellular respiration; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA binding; positive regulation of DNA biosynthetic process; positive regulation of DNA methylation; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of glycolytic process; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of mitochondrial membrane potential; positive regulation of oxidative phosphorylation; positive regulation of response to DNA damage stimulus; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein processing; protein-DNA complex disassembly; pyruvate transport; re-entry into mitotic cell cycle; regulation of apoptotic process; regulation of gene expression; regulation of mitotic cell cycle; regulation of oxidative phosphorylation; regulation of telomere maintenance; regulation of transcription, DNA-templated; response to alkaloid; response to gamma radiation; response to radiation; skeletal muscle cell differentiation; skeletal system morphogenesis; transcription by RNA polymerase II; transcription, DNA-templated; transformation of host cell by virus; Wnt signaling pathway
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Reference #:
P01108
(UniProtKB)
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Alt. Names/Synonyms: AU016757; bHLHe39; c-myc proto-oncogene; Myc; Myc proto-oncogene protein; Myc2; myelocytomatosis oncogene; Niard; Nird; Proto-oncogene c-Myc; Transcription factor p64
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Gene Symbols: Myc
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Molecular weight:
48,971 Da
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Basal Isoelectric point:
5.52
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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Growth And Differentiation Control by MAPKs
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Regulation of P38 MAPKs
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Warburg Effect
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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