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Myc
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor |
| Chromosomal Location of mouse Ortholog: 15 D1|15 26.19 cM |
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Cellular Component:
axon; chromatin; euchromatin; Myc-Max complex; nuclear body; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein-containing complex; RNA polymerase II transcription repressor complex; spindle
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; core promoter sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; E-box binding; protein binding; protein dimerization activity; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; SCF ubiquitin ligase complex binding; sequence-specific DNA binding; transcription coregulator binding; ubiquitin protein ligase binding
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Biological Process:
acinar cell proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; amino acid transport; B cell apoptotic process; branching involved in ureteric bud morphogenesis; cell population proliferation; cellular response to hypoxia; cellular response to interferon-alpha; cellular response to xenobiotic stimulus; chromatin remodeling; chromosome organization; detection of mechanical stimulus involved in sensory perception of sound; DNA damage response; DNA-templated transcription; DNA-templated transcription initiation; ERK1 and ERK2 cascade; G1/S transition of mitotic cell cycle; glucose metabolic process; inner mitochondrial membrane organization; intracellular iron ion homeostasis; intrinsic apoptotic signaling pathway in response to DNA damage; lactic acid secretion; MAPK cascade; middle ear morphogenesis; myotube differentiation; negative regulation of cell division; negative regulation of epithelial cell apoptotic process; negative regulation of fibroblast proliferation; negative regulation of gene expression; negative regulation of glucose import; negative regulation of monocyte differentiation; negative regulation of protein binding; negative regulation of transcription by RNA polymerase II; NK T cell proliferation; pigmentation; positive regulation of acinar cell proliferation; positive regulation of apoptotic signaling pathway; positive regulation of ATP biosynthetic process; positive regulation of B cell apoptotic process; positive regulation of catalytic activity; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of cellular respiration; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA binding; positive regulation of DNA methylation; positive regulation of DNA-templated transcription; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of glial cell proliferation; positive regulation of glycolytic process; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of miRNA transcription; positive regulation of mitochondrial membrane potential; positive regulation of oxidative phosphorylation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of telomerase activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; protein processing; protein-DNA complex disassembly; pyruvate transport; re-entry into mitotic cell cycle; regulation of apoptotic process; regulation of cell cycle process; regulation of DNA-templated transcription; regulation of gene expression; regulation of mitotic cell cycle; regulation of oxidative phosphorylation; regulation of somatic stem cell population maintenance; regulation of telomere maintenance; regulation of transcription by RNA polymerase II; response to alkaloid; response to gamma radiation; response to radiation; skeletal muscle cell differentiation; skeletal system morphogenesis; transcription by RNA polymerase II; Wnt signaling pathway
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Reference #:
P01108
(UniProtKB)
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Alt. Names/Synonyms: AU016757; bHLHe3; bHLHe39; c-myc proto-oncogene; Myc; Myc proto-oncogene protein; Myc2; myelocytomatosis oncogene; Niard; Nird; Proto-oncogene c-Myc; Transcription factor p64
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Gene Symbols: Myc
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Molecular weight:
50,678 Da
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Basal Isoelectric point:
5.38
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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Growth And Differentiation Control by MAPKs
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Regulation of P38 MAPKs
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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