COLQ
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina. Belongs to the COLQ family. Found at the end plate of skeletal muscle. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Extracellular matrix |
Chromosomal Location of human Ortholog: 3p25.1 |
Cellular Component:
basement membrane; cell junction; collagen trimer; collagen-containing extracellular matrix; extracellular space; neuromuscular junction; plasma membrane; synaptic cleft
|
Molecular Function:
extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; heparin binding; protein binding
|
Biological Process:
acetylcholine catabolic process in synaptic cleft; establishment of protein localization to membrane; extracellular matrix organization; regulation of synaptic assembly at neuromuscular junction; skeletal muscle acetylcholine-gated channel clustering
|
Disease: Endplate Acetylcholinesterase Deficiency
|
Reference #:
Q9Y215
(UniProtKB)
|
Alt. Names/Synonyms: Acetylcholinesterase collagenic tail peptide; Acetylcholinesterase-associated collagen; AChE Q subunit; CMS5; collagen like tail subunit of asymmetric acetylcholinesterase; collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase; collagenic tail of endplate acetylcholinesterase; COLQ; EAD; FLJ55041; single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
|
Gene Symbols: COLQ
|
Molecular weight:
47,766 Da
|
Basal Isoelectric point:
8.42
Predict pI for various phosphorylation states
|