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MUC1
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only. 17 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 3 F1|3 39.02 cM |
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Cellular Component:
apical plasma membrane; cell surface; chromatin; cytoplasm; extracellular exosome; membrane; nucleus; plasma membrane
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Molecular Function:
p53 binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription coregulator activity
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Biological Process:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; localization; negative regulation of cell adhesion mediated by integrin; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of transcription by competitive promoter binding; positive regulation of histone H4 acetylation; positive regulation of transcription from RNA polymerase II promoter in response to stress; regulation of transcription from RNA polymerase II promoter in response to stress
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Reference #:
Q02496
(UniProtKB)
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Alt. Names/Synonyms: CD227; EMA; Episialin; MUC-1; Muc1; MUC1-alpha; MUC1-beta; MUC1-CT; MUC1-NT; mucin 1, transmembrane; Mucin-1; Mucin-1 subunit alpha; Mucin-1 subunit beta; OTTMUSP00000021969
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Gene Symbols: Muc1
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Molecular weight:
64,539 Da
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Basal Isoelectric point:
5.33
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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