CAPZA2 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Belongs to the F-actin-capping protein alpha subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q31.2
Cellular Component:  actin cytoskeleton; brush border; cytosol; extracellular region; membrane
Molecular Function:  protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; ER to Golgi vesicle-mediated transport; innate immune response; protein-containing complex assembly
Reference #:  P47755 (UniProtKB)
Alt. Names/Synonyms: CAPPA2; capping protein (actin filament) muscle Z-line, alpha 2; CAPZ; CapZ alpha-2; CAPZA2; CAZA2; F-actin capping protein alpha-2 subunit; F-actin-capping protein subunit alpha-2
Gene Symbols: CAPZA2
Molecular weight: 32,949 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene