MLK3 Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 19 A|19 4.34 cM
Cellular Component:  centrosome; cytoplasm; cytoskeleton; microtubule
Molecular Function:  ATP binding; identical protein binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding; transferase activity
Biological Process:  activation of JNKK activity; activation of JUN kinase activity; activation of MAPK activity; cell death; cell proliferation; JNK cascade; MAPK cascade; microtubule-based process; phosphorylation; positive regulation of apoptotic process; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; protein autophosphorylation; protein phosphorylation
Reference #:  Q80XI6 (UniProtKB)
Alt. Names/Synonyms: 2610017K16Rik; M3K11; Map3k11; mitogen activated protein kinase kinase kinase 11; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Mlk3; PTK1; SPRK
Gene Symbols: Map3k11
Molecular weight: 93,226 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MLK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene