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CDK5R1
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. Belongs to the cyclin-dependent kinase 5 activator family. Brain and neuron specific. Note: This description may include information from UniProtKB.
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| Protein type: Protein kinase, regulatory subunit |
| Chromosomal Location of rat Ortholog: 10q26 |
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Cellular Component:
axon; contractile fiber; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; dendrite; dendritic spine; growth cone; intracellular membrane-bounded organelle; membrane; neuromuscular junction; neuronal cell body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; presynapse; protein kinase 5 complex
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Molecular Function:
actin binding; actin filament binding; cadherin binding; calcium ion binding; cyclin-dependent protein serine/threonine kinase activator activity; ephrin receptor binding; Hsp90 protein binding; ionotropic glutamate receptor binding; kinase activity; protease binding; protein binding; protein kinase binding; protein serine/threonine kinase activator activity
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Biological Process:
axon extension; axon guidance; axonal fasciculation; brain development; cerebellum development; cerebral cortex radially oriented cell migration; embryo development ending in birth or egg hatching; ephrin receptor signaling pathway; G protein-coupled acetylcholine receptor signaling pathway; G1 to G0 transition involved in cell differentiation; hippocampus development; ionotropic glutamate receptor signaling pathway; layer formation in cerebral cortex; negative regulation of DNA-templated transcription; neuron cell-cell adhesion; neuron differentiation; neuron migration; neuron projection development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of MHC class II biosynthetic process; positive regulation of neuron apoptotic process; positive regulation of protein kinase activity; positive regulation of protein targeting to membrane; positive regulation of signaling receptor activity; regulation of actin cytoskeleton organization; regulation of dendritic spine morphogenesis; regulation of microtubule cytoskeleton organization; regulation of synaptic vesicle cycle; rhythmic process; serine phosphorylation of STAT protein; superior olivary nucleus maturation
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Reference #:
P61810
(UniProtKB)
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Alt. Names/Synonyms: CD5R1; CDK5 activator 1; Cdk5r; Cdk5r1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1, p35; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1; p23; p25; p35; Tau protein kinase II 23 kDa subunit; TPKII regulatory subunit
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Gene Symbols: Cdk5r1
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Molecular weight:
34,031 Da
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Basal Isoelectric point:
9.44
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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