FRAT1 Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. Belongs to the GSK-3-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription regulation
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component:  cytoplasm; cytosol; intracellular membrane-bounded organelle
Molecular Function:  protein binding
Biological Process:  beta-catenin destruction complex disassembly; canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway
Reference #:  Q92837 (UniProtKB)
Alt. Names/Synonyms: FLJ97193; FRAT regulator of WNT signaling pathway 1; FRAT-1; FRAT1; FRAT1, WNT signaling pathway regulator; frequently rearranged in advanced T-cell lymphomas; Frequently rearranged in advanced T-cell lymphomas 1; GBP; Proto-oncogene FRAT1
Gene Symbols: FRAT1
Molecular weight: 29,093 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below

FRAT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene