MKK7 Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 2.7.12.2; Kinase, protein; MEK7 subfamily; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Chromosomal Location of mouse Ortholog: 8|8 A1.1

Cellular Component: cytoplasm; nucleus

Molecular Function: ATP binding; enzyme binding; JUN kinase kinase activity; magnesium ion binding; MAP kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; molecular function activator activity; protein binding; protein kinase binding; protein phosphatase binding

Biological Process: cellular response to interleukin-1; cellular response to lipopolysaccharide; cellular response to osmotic stress; JNK cascade; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of neuron apoptotic process; positive regulation of protein phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein phosphorylation; regulation of motor neuron apoptotic process; response to heat; response to osmotic stress; response to tumor necrosis factor; response to UV; response to wounding; stress-activated MAPK cascade

Reference #: Q8CE90 (UniProtKB)

Alt. Names/Synonyms: 5930412N11Rik; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; Jnkk; JNKK 2; Jnkk2; MAP kinase kinase 7; Map2k7; MAPK/ERK kinase 7; MAPKK 7; Mapkk7; MEK 7; Mek7; mitogen activated protein kinase kinase 7; mitogen-activated protein kinase kinase 7; Mkk7; MP2K7; OTTMUSP00000017733; OTTMUSP00000017734; Prkm; Prkmk7; protein kinase, mitogen activated, kinase 7; sek; sek2

Gene Symbols: Map2k7

Molecular weight: 59,312 Da

Basal Isoelectric point: 9.28 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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MKK7

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