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SFRS17A
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. Widely expressed. Found in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Expressed in activated B-cells and placenta. Expressed in all cell lines tested including Jurkat-TAg, U-937 and HEK293 cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing |
| Chromosomal Location of human Ortholog: X;Y |
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Cellular Component:
cytosol; nuclear speck; nucleus; spliceosomal complex
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Molecular Function:
protein binding; protein kinase A binding
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Biological Process:
B cell activation; mRNA processing; regulation of DNA-templated transcription; regulation of RNA splicing; RNA splicing; signal transduction
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Reference #:
Q02040
(UniProtKB)
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Alt. Names/Synonyms: 721P; A kinase (PRKA) anchor protein 17A; A-kinase anchor protein 17A; A-kinase anchoring protein 17A; AK17A; AKAP-17A; AKAP17A; B-lymphocyte antigen; B-lymphocyte surface antigen; CCDC133; CXYorf3; DXYS155E; MGC125365; MGC125366; MGC39904; PRKA17A; Protein kinase A-anchoring protein 17A; Protein XE7; pseudoautosomal gene XE7; SF17A; SFRS17A; Splicing factor, arginine/serine-rich 17A; XE7; XE7Y
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Gene Symbols: AKAP17A
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Molecular weight:
80,735 Da
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Basal Isoelectric point:
9.76
Predict pI for various phosphorylation states
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