Met Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis. (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Met family; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 6 A2|6 7.83 cM
Cellular Component:  basal plasma membrane; cytoplasm; dendrite; excitatory synapse; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; neuron projection; neuronal cell body; plasma membrane; postsynaptic density; postsynaptic membrane; receptor complex; sperm flagellum
Molecular Function:  ATP binding; beta-catenin binding; hepatocyte growth factor-activated receptor activity; identical protein binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; phospholipase binding; protein binding; protein heterodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding
Biological Process:  activation of MAPK activity; adult behavior; brain development; branching morphogenesis of an epithelial tube; cardiac muscle cell development; cardiac muscle contraction; cell migration; chemical synaptic transmission; endothelial cell morphogenesis; establishment of skin barrier; excitatory postsynaptic potential; flagellated sperm motility; glucose homeostasis; hepatocyte growth factor receptor signaling pathway; liver development; modulation of chemical synaptic transmission; muscle cell migration; muscle organ development; myoblast proliferation; myotube differentiation; negative regulation of gene expression; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of hydrogen peroxide-mediated programmed cell death; negative regulation of peptidyl-threonine phosphorylation; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta production; nervous system development; neuron differentiation; neuron migration; pancreas development; phagocytosis; phosphorylation; placenta development; positive chemotaxis; positive regulation of dendrite morphogenesis; positive regulation of DNA replication; positive regulation of endothelial cell chemotaxis; positive regulation of gene expression; positive regulation of glucose transmembrane transport; positive regulation of microtubule polymerization; positive regulation of mitotic nuclear division; positive regulation of neuron projection development; positive regulation of p38MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of transcription by RNA polymerase II; protein autophosphorylation; protein phosphorylation; reactive oxygen species metabolic process; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; regulation of cellular response to oxidative stress; regulation of interleukin-6 production; semaphorin-plexin signaling pathway; skeletal muscle tissue development; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt signaling pathway
Reference #:  P16056 (UniProtKB)
Alt. Names/Synonyms: AI838057; c-Met; Hepatocyte growth factor receptor; HGF; HGF receptor; HGF/SF receptor; HGFR; Met; met proto-oncogene; met proto-oncogene tyrosine kinase; OTTMUSP00000028498; OTTMUSP00000028499; Par4; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
Gene Symbols: Met
Molecular weight: 153,549 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene