KCNJ8 This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ8 subfamily. Predominantly detected in fetal and adult heart. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component:  inward rectifying potassium channel; mitochondrion; myofibril; plasma membrane; sarcolemma; voltage-gated potassium channel complex
Molecular Function:  ATP binding; ATP-activated inward rectifier potassium channel activity; sulfonylurea receptor binding; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Biological Process:  defense response to virus; heart development; kidney development; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion import across plasma membrane; potassium ion transport; regulation of ion transmembrane transport; response to exogenous dsRNA; response to lipopolysaccharide
Reference #:  Q15842 (UniProtKB)
Alt. Names/Synonyms: ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifying potassium channel KIR6.1; IRK8; KCNJ8; KIR6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly rectifying channel subfamily J member 8; potassium inwardly-rectifying channel J8; potassium inwardly-rectifying channel, subfamily J, member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1
Gene Symbols: KCNJ8
Molecular weight: 47,968 Da
Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB