ADAM12 Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component:  integral component of membrane; membrane; nucleoplasm; plasma membrane
Molecular Function:  hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; SH3 domain binding
Biological Process:  cell adhesion; positive regulation of angiogenesis; proteolysis
Reference #:  Q61824 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 12 (meltrin alpha); a disintegrin and metalloprotease domain 12; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADA12; ADAM; ADAM 12; Adam12; Disintegrin and metalloproteinase domain-containing protein 12; KIAA4001; meltrin alpha; Meltrin-alpha; mKIAA4001; Mltna; OTTMUSP00000023508
Gene Symbols: Adam12
Molecular weight: 98,504 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene