ADAM12 contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component:  integral component of membrane; membrane; nucleoplasm; plasma membrane
Molecular Function:  hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; SH3 domain binding
Biological Process:  cell adhesion; positive regulation of angiogenesis; proteolysis
Reference #:  Q61824 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 12 (meltrin alpha); a disintegrin and metalloprotease domain 12; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADA12; ADAM 12; Adam12; Disintegrin and metalloproteinase domain-containing protein 12; KIAA4001; meltrin alpha; Meltrin-alpha; mKIAA4001; Mltna; OTTMUSP00000023508
Gene Symbols: Adam12
Molecular weight: 98,504 Da
Basal Isoelectric point: 8.74  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene