|
ADAM12
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease |
| Chromosomal Location of mouse Ortholog: 7|7 F3 |
|
Cellular Component:
membrane; nucleoplasm; plasma membrane
|
|
Molecular Function:
hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; SH3 domain binding
|
|
Biological Process:
cell adhesion; positive regulation of angiogenesis; proteolysis
|
|
Reference #:
Q61824
(UniProtKB)
|
|
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 12 (meltrin alpha); a disintegrin and metalloprotease domain 12; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADA12; ADAM; ADAM 12; Adam12; Disintegrin and metalloproteinase domain-containing protein 12; KIAA4001; meltrin alpha; Meltrin-alpha; mKIAA4001; Mltna; OTTMUSP00000023508
|
|
Gene Symbols: Adam12
|
|
Molecular weight:
98,504 Da
|
|
Basal Isoelectric point:
8.74
Predict pI for various phosphorylation states
|
