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MEF2C
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1. Belongs to the MEF2 family. Expressed in brain and skeletal muscle. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 13 C3|13 43.68 cM |
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Cellular Component:
cytoplasm; cytosol; intracellular membrane-bounded organelle; nuclear speck; nucleoplasm; nucleus; protein-containing complex; sarcomere
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Molecular Function:
chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; histone deacetylase binding; HMG box domain binding; minor groove of adenine-thymine-rich DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding
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Biological Process:
apoptotic process; B cell homeostasis; B cell proliferation; B cell receptor signaling pathway; blood vessel development; blood vessel remodeling; cardiac muscle cell differentiation; cardiac muscle hypertrophy in response to stress; cardiac ventricle formation; cartilage morphogenesis; cell differentiation; cell fate commitment; cell morphogenesis involved in neuron differentiation; cell proliferation in bone marrow; cellular response to calcium ion; cellular response to fluid shear stress; cellular response to growth factor stimulus; cellular response to lipopolysaccharide; cellular response to parathyroid hormone stimulus; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; cellular response to xenobiotic stimulus; chondrocyte differentiation; embryonic heart tube development; embryonic skeletal system morphogenesis; embryonic viscerocranium morphogenesis; endochondral ossification; epithelial cell proliferation involved in renal tubule morphogenesis; excitatory postsynaptic potential; gene expression; germinal center formation; glomerulus morphogenesis; heart development; heart looping; humoral immune response; learning or memory; MAPK cascade; melanocyte differentiation; monocyte differentiation; multicellular organism development; muscle cell fate determination; negative regulation of blood vessel endothelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of gene expression; negative regulation of neuron apoptotic process; negative regulation of ossification; negative regulation of transcription by RNA polymerase II; negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular endothelial cell proliferation; nephron tubule epithelial cell differentiation; nervous system development; neural crest cell differentiation; neuron development; neuron differentiation; neuron migration; osteoblast differentiation; outflow tract morphogenesis; platelet formation; positive regulation of alkaline phosphatase activity; positive regulation of B cell proliferation; positive regulation of behavioral fear response; positive regulation of bone mineralization; positive regulation of cardiac muscle cell differentiation; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell proliferation in bone marrow; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of macrophage apoptotic process; positive regulation of MAP kinase activity; positive regulation of myoblast differentiation; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle cell differentiation; positive regulation of skeletal muscle tissue development; positive regulation of transcription by RNA polymerase II; primary heart field specification; regulation of AMPA receptor activity; regulation of dendritic spine development; regulation of DNA-templated transcription; regulation of germinal center formation; regulation of megakaryocyte differentiation; regulation of neuron apoptotic process; regulation of neurotransmitter secretion; regulation of NMDA receptor activity; regulation of sarcomere organization; regulation of synapse assembly; regulation of synaptic activity; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; renal tubule morphogenesis; response to ischemia; roof of mouth development; secondary heart field specification; semaphorin-plexin signaling pathway involved in axon guidance; sinoatrial valve morphogenesis; skeletal muscle cell differentiation; skeletal muscle tissue development; smooth muscle cell differentiation; sympathetic neuron axon guidance; transdifferentiation; ventricular cardiac muscle cell differentiation
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Reference #:
Q8CFN5
(UniProtKB)
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Alt. Names/Synonyms: 5430401D19Rik; 9930028G15Rik; AV011172; Mef2; Mef2c; myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C
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Gene Symbols: Mef2c
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Molecular weight:
51,278 Da
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Basal Isoelectric point:
8.14
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Regulation of P38 MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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