WDR77 a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus
Molecular Function:  ligand-dependent nuclear receptor transcription coactivator activity; methyl-CpG binding; protein binding; protein-arginine N-methyltransferase activity
Biological Process:  peptidyl-arginine N-methylation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis
Reference #:  Q9BQA1 (UniProtKB)
Alt. Names/Synonyms: Androgen receptor cofactor p44; HKMT1069; MEP-50; MEP50; Methylosome protein 50; MGC2722; Nbla10071; p44; p44/Mep50; RP11-552M11.3; WD repeat domain 77; WD repeat-containing protein 77; WDR77
Gene Symbols: WDR77
Molecular weight: 36,724 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA