MEF2A Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. Belongs to the MEF2 family. Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of mouse Ortholog: 7 C|7 36.72 cM
Cellular Component:  chromatin; cytosol; nucleoplasm; nucleus; transcription regulator complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; histone acetyltransferase binding; histone deacetylase binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; SMAD binding
Biological Process:  apoptotic process; cardiac conduction; cell differentiation; cellular response to calcium ion; dendrite morphogenesis; DNA-templated transcription; ERK5 cascade; heart development; MAPK cascade; mitochondrial genome maintenance; mitochondrion distribution; multicellular organism development; negative regulation of transcription by RNA polymerase II; nervous system development; positive regulation of cardiac muscle hypertrophy; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of glucose import; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; ventricular cardiac myofibril assembly
Reference #:  Q60929 (UniProtKB)
Alt. Names/Synonyms: A430079H05Rik; Mef2a; myocyte enhancer factor 2A; Myocyte-specific enhancer factor 2A; OTTMUSP00000023285
Gene Symbols: Mef2a
Molecular weight: 53,579 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  ErbB/HER Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene