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ANP-C
a transmembrane guanylyl cyclase enzyme. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 5p13.3 |
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Cellular Component:
plasma membrane; protein-containing complex
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Molecular Function:
chloride ion binding; G protein-coupled peptide receptor activity; hormone binding; natriuretic peptide receptor activity; peptide binding; peptide hormone binding; protein binding; protein homodimerization activity
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Biological Process:
angiogenesis; blood vessel remodeling; G protein-coupled receptor signaling pathway; negative regulation of cold-induced thermogenesis; osteoclast proliferation; positive regulation of nitric-oxide synthase activity; positive regulation of urine volume; regulation of blood pressure; regulation of osteoblast proliferation; response to ischemia; signal transduction; skeletal system development
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Disease: Boudin-mortier Syndrome
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Reference #:
P17342
(UniProtKB)
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Alt. Names/Synonyms: ANP-C; ANPR-C; ANPRC; Atrial natriuretic peptide clearance receptor; Atrial natriuretic peptide receptor 3; Atrial natriuretic peptide receptor type C; atrionatriuretic peptide receptor C; C5orf23; guanylate cyclase C; GUCY2B; natriuretic peptide receptor 3; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); NPR-C; NPR3; NPRC
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Gene Symbols: NPR3
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Molecular weight:
59,808 Da
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Basal Isoelectric point:
5.93
Predict pI for various phosphorylation states
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