DNAJB6
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; Z disc
Molecular Function: ATPase activator activity; DNA binding; heat shock protein binding; Hsp70 protein binding; identical protein binding; protein binding; protein folding chaperone; protein-folding chaperone binding; unfolded protein binding
Biological Process: actin cytoskeleton organization; chaperone-mediated protein folding; chorio-allantoic fusion; chorion development; extracellular matrix organization; intermediate filament organization; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of inclusion body assembly; protein folding; protein localization to nucleus; regulation of protein localization; syncytiotrophoblast cell differentiation involved in labyrinthine layer development
