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MARCKS
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. Belongs to the MARCKS family. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 10 B1|10 19.49 cM |
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Cellular Component:
actin filament bundle; axon terminus; bleb; cell cortex; centrosome; chromatoid body; cytoplasm; cytoskeleton; dendritic branch; dendritic spine; germinal vesicle; glutamatergic synapse; growth cone; membrane; microtubule; organelle; outer dense fiber; plasma membrane; postsynaptic cytoskeleton; postsynaptic membrane; presynaptic cytosol; presynaptic membrane
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Molecular Function:
actin binding; actin filament binding; calmodulin binding; identical protein binding; phosphatidylserine binding; phospholipid binding; protein kinase C binding
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Biological Process:
actin crosslink formation; actin filament bundle assembly; actin filament organization; activation of phospholipase D activity; apoptotic process; cell-substrate adhesion; central nervous system development; intracellular protein transport; mitochondrion organization; neural tube development; neurogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of insulin receptor signaling pathway; positive regulation of neuron projection development; positive regulation of protein kinase C activity; regulation of modification of postsynaptic actin cytoskeleton; response to endoplasmic reticulum stress
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Reference #:
P26645
(UniProtKB)
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Alt. Names/Synonyms: 80K protein; Macs; MARCKS; MARCS; myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; PKCSL
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Gene Symbols: Marcks
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Molecular weight:
29,661 Da
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Basal Isoelectric point:
4.34
Predict pI for various phosphorylation states
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CST Pathways:
Protein Kinase C Signaling
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