ROCK2 Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); ROCK subfamily
Cellular Component:  cytosol; microtubule organizing center; nucleus; plasma membrane
Molecular Function:  ATP binding; metal ion binding; protein kinase activity; protein serine/threonine kinase activity; Rho GTPase binding
Biological Process:  actin cytoskeleton organization; positive regulation of centrosome duplication; protein phosphorylation; regulation of actin cytoskeleton organization; regulation of circadian rhythm; Rho protein signal transduction; rhythmic process; smooth muscle contraction
Reference #:  Q28021 (UniProtKB)
Alt. Names/Synonyms: p164 ROCK-2; Rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; ROCK2
Gene Symbols: ROCK2
Molecular weight: 160,800 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  Apoptosis Regulation  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ROCK2

Protein Structure Not Found.


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Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene