MAP2 The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1 C3|1 33.49 cM
Cellular Component:  actin cytoskeleton; apical distal dendrite; axon hillock; axon initial segment; basal dendrite; CA3 pyramidal cell dendrite; cell body; cell projection; cytoplasm; cytoskeleton; cytosol; dendrite; dendrite cytoplasm; dendritic branch; dendritic filopodium; dendritic growth cone; dendritic shaft; distal dendrite; microtubule; microtubule associated complex; microtubule cytoskeleton; neuron projection; neuronal cell body; nuclear periphery; nucleolus; postsynaptic density; primary dendrite; protein-containing complex; proximal dendrite; proximal neuron projection; rough endoplasmic reticulum; ruffle membrane; smooth endoplasmic reticulum
Molecular Function:  actin binding; calmodulin binding; cytoskeletal regulatory protein binding; dystroglycan binding; microtubule binding; protein binding; protein kinase binding; tubulin binding
Biological Process:  axonogenesis; cellular response to organic substance; central nervous system neuron development; dendrite development; establishment of cell polarity; microtubule bundle formation; microtubule cytoskeleton organization; negative regulation of axon extension; negative regulation of microtubule binding; negative regulation of microtubule depolymerization; negative regulation of microtubule motor activity; negative regulation of microtubule polymerization; neuron projection development; positive regulation of anterograde dense core granule transport; positive regulation of anterograde synaptic vesicle transport; regulation of cellular protein localization; regulation of organelle transport along microtubule
Reference #:  P20357 (UniProtKB)
Alt. Names/Synonyms: MAP-2; Map2; Microtubule-associated protein 2; Mtap-2; Mtap2; OTTMUSP00000017688; OTTMUSP00000017689; OTTMUSP00000017691
Gene Symbols: Map2
Molecular weight: 199,132 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene