LYN a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 4 A1|4 2.05 cM
Cellular Component:  cell-cell adherens junction; cytoplasm; extrinsic component of cytoplasmic side of plasma membrane; glutamatergic synapse; Golgi apparatus; integrin alpha2-beta1 complex; intracellular membrane-bounded organelle; membrane; membrane raft; mitochondrial crista; mitochondrial intermembrane space; mitochondrial membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; postsynaptic specialization, intracellular component
Molecular Function:  ATP binding; enzyme binding; ephrin receptor binding; erythropoietin receptor binding; gamma-tubulin binding; glycosphingolipid binding; integrin binding; ion channel binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; phosphoprotein binding; phosphorylation-dependent protein binding; platelet-derived growth factor receptor binding; protein binding; protein kinase activity; protein tyrosine kinase activity; protein-containing complex binding; SH3 domain binding; signaling receptor binding; transferase activity; ubiquitin protein ligase binding
Biological Process:  adaptive immune response; B cell homeostasis; B cell receptor signaling pathway; cell differentiation; cellular response to DNA damage stimulus; cellular response to retinoic acid; cytokine secretion; dendritic cell differentiation; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; hemoglobin biosynthetic process; hemopoiesis; histamine secretion by mast cell; immune response-regulating cell surface receptor signaling pathway; immune system process; inflammatory response; innate immune response; intracellular signal transduction; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of intracellular signal transduction; negative regulation of MAP kinase activity; negative regulation of mast cell proliferation; negative regulation of myeloid leukocyte differentiation; negative regulation of protein phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; neuron projection development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; platelet degranulation; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of dendritic cell apoptotic process; positive regulation of Fc receptor mediated stimulatory signaling pathway; positive regulation of glial cell proliferation; positive regulation of mast cell proliferation; positive regulation of neuron projection development; positive regulation of oligodendrocyte progenitor proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphorylation; positive regulation of protein phosphorylation; positive regulation of stress-activated protein kinase signaling cascade; positive regulation of tyrosine phosphorylation of STAT protein; protein autophosphorylation; protein phosphorylation; regulation of B cell apoptotic process; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of cytokine secretion; regulation of ERK1 and ERK2 cascade; regulation of erythrocyte differentiation; regulation of inflammatory response; regulation of mast cell activation; regulation of mast cell degranulation; regulation of monocyte chemotaxis; regulation of platelet aggregation; regulation of release of sequestered calcium ion into cytosol; response to hormone; signal transduction; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P25911 (UniProtKB)
Alt. Names/Synonyms: AA407514; Hck-2; Lyn; OTTMUSP00000004775; Tyrosine-protein kinase Lyn; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Gene Symbols: Lyn
Molecular weight: 58,812 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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LYN

Protein Structure Not Found.


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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene