TRAF3IP1 Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis. Belongs to the TRAF3IP1 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component:  axoneme; ciliary basal body; ciliary base; ciliary tip; ciliary transition zone; cilium; intraciliary transport particle B
Molecular Function:  microtubule binding; protein binding
Biological Process:  embryonic camera-type eye development; embryonic digit morphogenesis; embryonic heart tube development; intraciliary transport involved in cilium assembly; kidney development; morphogenesis of a polarized epithelium; negative regulation of defense response to virus; negative regulation of interferon-beta production; negative regulation of protein complex assembly; negative regulation of protein phosphorylation; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; negative regulation of type I interferon production; neural tube patterning; post-anal tail morphogenesis; regulation of microtubule cytoskeleton organization
Disease: Senior-loken Syndrome 9
Reference #:  Q8TDR0 (UniProtKB)
Alt. Names/Synonyms: DKFZp434F124; FAP116; IFT54; interleukin 13 receptor alpha 1-binding protein-1; Interleukin-13 receptor alpha 1-binding protein 1; Intraflagellar transport protein 54 homolog; microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; microtubule-interacting protein that associates with TRAF3; MIP-T3; MIPT3; SLSN9; TNF receptor-associated factor 3 interacting protein 1; TRAF3 interacting protein 1; TRAF3-interacting protein 1; TRAF3IP1
Gene Symbols: TRAF3IP1
Molecular weight: 78,632 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
Select Structure to View Below

TRAF3IP1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein