LIMK1 Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 5 74.73 cM|5 G2
Cellular Component:  axonal growth cone; cell projection; cytoplasm; cytosol; focal adhesion; Golgi apparatus; lamellipodium; membrane; neuron projection; nuclear speck; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; heat shock protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein heterodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton organization; negative regulation of ubiquitin-protein transferase activity; phosphorylation; positive regulation of actin filament bundle assembly; positive regulation of axon extension; positive regulation of stress fiber assembly; protein phosphorylation
Reference #:  P53668 (UniProtKB)
Alt. Names/Synonyms: KIZ-1; LIM domain kinase 1; LIM-domain containing, protein kinase; Limk; LIMK-1; Limk1; OTTMUSP00000032203
Gene Symbols: Limk1
Molecular weight: 72,793 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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LIMK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene