ARHGAP29 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 3|3 G1
Cellular Component:  cytoplasm; protein-containing complex
Molecular Function:  GTPase activator activity; metal ion binding; PDZ domain binding; protein binding
Biological Process:  intracellular signal transduction; signal transduction
Reference #:  Q8CGF1 (UniProtKB)
Alt. Names/Synonyms: 6720461J18Rik; A830014I19; Arhgap29; AU040217; B130017I01Rik; C76601; Parg1; PTPL1-associated RhoGAP 1; RHG29; Rho GTPase activating protein 29; Rho GTPase-activating protein 29; Rho-type GTPase-activating protein 29
Gene Symbols: Arhgap29
Molecular weight: 142,341 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene