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CREB3L2
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. Belongs to the bZIP family. ATF subfamily. Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Oncoprotein; Transcription factor |
| Chromosomal Location of human Ortholog: 7q33 |
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Cellular Component:
chromatin; endoplasmic reticulum; endoplasmic reticulum membrane; nucleoplasm; nucleus; perinuclear endoplasmic reticulum
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Molecular Function:
cAMP response element binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding
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Biological Process:
cartilage development; chondrocyte differentiation; endoplasmic reticulum to Golgi vesicle-mediated transport; endoplasmic reticulum unfolded protein response; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of neuron projection development; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; response to endoplasmic reticulum stress; response to wounding
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Reference #:
Q70SY1
(UniProtKB)
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Alt. Names/Synonyms: B-ZIB transcription factor; basic transcription factor 2; BBF2 human homolog on chromosome 7; BBF2H7; cAMP responsive element binding protein 3 like 2; cAMP responsive element binding protein 3-like 2; cAMP-responsive element-binding protein 3-like protein 2; CR3L2; CREB3L2; Cyclic AMP-responsive element-binding protein 3-like protein 2; FUS/BBF2H7 protein; MGC131709; MGC71006; Processed cyclic AMP-responsive element-binding protein 3-like protein 2; TCAG_1951439
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Gene Symbols: CREB3L2
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Molecular weight:
57,415 Da
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Basal Isoelectric point:
5.3
Predict pI for various phosphorylation states
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